报告题目：Re-wiring Mammalian Cell Signaling through Chemical Synthetic Biology Approaches
报告人：Fu-sen Liang（美国Case Western Reserve University）
Dr Fu-sen Liang received B.S and M.S from National Taiwan University, and his Ph.D degree from The Scripps Research Institute in 2005. Then he joined the Stanford University School of Medicine a Postdoctoral Fellow. His group develops new interdisciplinary strategies based on chemistry and applying the concept of controlling proximity to regulate RNAs and to engineer mammalian cells. The current research focuses include the development of novel molecules to control the function of miRNAs, the inducible editing platforms for epigenetic research, and new chemistry-based synthetic biology approaches to create artificial synthetic cells. Using these unique technologies, we aim to understand the posttranscriptional regulatory mechanisms in gene expression and to develop new therapies using synthetic molecules and cells for treating cancers and other human diseases.
Cell signaling controls how a cell responds to external signals and generates appropriate biological effects to maintain cellular functions. The ability to re-wire cell signaling allows the re-programming of mammalian cells to introduce tailored functional outputs with user-defined controls. In this seminar, we will discuss our efforts in developing a unique chemical synthetic biology strategy that integrates chemical reactivity-based signal sensing and chemically induced protein dimerization technologies to enable cells to translate different types of extracellular signals under pre-defined processing rules into precise biological outputs. This new strategy can potentially lead to novel cell-based therapies for different human diseases.